Background: Schizophrenia is a complex syndrome that commonly occurs between 20 and 25 years. The symptoms after the first psychotic episode are the aggravation of those presented at the prodrome phase and divides in three groups: negative, positive, and cognitive symptoms. Aim: to identify factors that modify the quality of life of patients with schizophrenia. Methodology: it is a systematic review of the literature, whose articles were selected from the last 5 years of PubMed, IBECS and LILACS following the PRISMA-P checklist and Cochrane guideline. The final sample was evaluatedby independent evaluators. Results: eight articles were analyzed and all of then found a global decrease in quality of life in the schizophrenic population. The preponderant factors for the lower quality of life of these patients divides into environmental factors, intrinsic to the individual and clinical presentation. Conclusion: the importance of encouraging the practice of physical activity and smoking cessation, the intrinsic factors found can be anticipated and somewhat mitigated by encouraging continued psychotherapy. Finally, when it comes to symptom spheres, this research brought an alarming situation that may be a consequence of the neglect of negative and cognitive symptoms in the therapeutic planning of these patients.
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