The corrected incidence of BJI in northern France, according to consensus diagnostic criteria, was 7.1/100 000 children <16 years of age.

We report a case of Xp21 deletion syndrome, a contiguous gene syndrome associating glycerol kinase deficiency, Duchenne muscular dystrophy, and congenital adrenal hypoplasia. This results in a contraindication to the use of all halogenated agents and of propofol. We used regional anesthesia combined with dexmedetomidine and ketamine. Previously, the patient had received inadvertently a propofol-based total intravenous anesthesia (TIVA) with no clinical side effects. We were unfortunately unable to document the metabolic consequences of this glycerol load. We suggest that if propofol is deemed necessary in such cases, it should only be used as a bolus dose of a 2% solution.

Letter to the Editor Pharmacokinetics of colistin in a 8-year-old child with acute bone infection Colistin pharmacokinetics (PK) has been recently extensively revisited [1,2], but limited and sometimes conflicting information is available for paediatric patients [3]. Further, the dosing regimen currently recommended for children by the European Medicines Agency (EMA) for the colistin methanesulfonate (CMS) prodrug (75 000 to 150 000 IU/kg per day) seems likely to result in suboptimal colistin plasma concentrations [3]. We report the case of a 8-year-old boy weighing 25 kg, 1.35 m in height and a plasma creatinine of 35 mmol/L, corresponding to a Contents lists available at ScienceDirect Clinical Microbiology and Infection j o u r n a l h o m e p a g e : w w w. c l i n i c a l m i c r o b i o l o g y a n d i n f e c t i o n. c o m

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