The present study aimed to evaluate the anti-inflammatory potential of a Lycium barbarum (L. barbarum) fruit extract in Wistar rats submitted to a palatable diet presenting systemic inflammation induced by lipopolysaccharides (LPS). Forty-two Wistar female rats (Rattus Novergicus) were used with 60 days old. The animals were feed for 60 days and divided in six groups (n=7): standard diet+water; standard diet+L. barbarum; palatable diet+water; palatable diet+L. barbarum; standard diet+water+LPS; standard diet+L. barbarum+LPS. A significant difference was shown between the analyzed groups concerning C-reactive protein, with the standard diet+water+LPS group presenting the highest inflammatory response in comparison to the other groups. Decreased inflammatory response was observed in the group administered a palatable diet along with the fruit extract when compared to the group that received only a palatable diet. Significant decrease in glutamic-oxaloacetic transaminase activity was observed in the standard diet+L. barbarum+LPS group compared to the standard diet+water group, as well as in the palatable diet+L. HIGHLIGHTS  Lycium barbarum extract displays the potential to reduce inflammatory responses.  L. barbarum promotes the reduction of the inflammatory response in the palatable diet.  L. barbarum reduced glutamic-oxaloacetic transaminase activity in the both diets.  L. barbarum increase the expression of TNF-α and IL-6 genes in the standard diet. 2 Ávila, C.N.; et al.

This study aimed to analyze the effects of Goji Berry extract (GB, Lycium barbarum) gavage administration on liver tissue oxidative stress in Wistar rats as well as to identify and quantify the content of the major bioactive compounds of the fruit. Four diets were applied: SW -standard diet + water; SG -standard HIGHLIGHTS• L. barbarum promote the increase in catalase enzyme activity in the liver of rats.• L. barbarum increase mRNA expression of catalase enzyme in the liver of rats.• L. barbarum extract produced a significant oxidation decrease in the liver of rats.• L. barbarum extract has a significant amount of bioactive compounds.