We declare no confl ict of interest. Fosfomycin in vitro resistance of Escherichia coli from the communityIt is common practice in many places all over Brazil to use fosfomycin in the treatment of uncomplicated urinary tract infections, although resistance profi le is not currently well-known in our country.We would like to report the fi ndings of in vitro activity of fosfomycin against 240 nonduplicate consecutive E. coli strains isolated from community urinary samples (> 10 5 CFU/ mL in October 2009) from Curitiba (Paraná, Brazil). Susceptibility test were performed according to CLSI, using disk diffusion with 200 mg of fosfomycin disk with zone diameter breakpoint as recommended by CLSI.1 Clinical data were not evaluated and no statistical analysis was performed, considering the descriptive nature of the study.The susceptibility of E. coli to fosfomycin was 98.8% and to other antibiotics ranged from 66.3 -99.2% as follows: sulfamethoxazole (66.3%), nalidixic acid (78.3%), quinolones (81.3%, including ciprofl oxacin, levofl oxacin and norfl oxacin), amoxicillin/clavulanic acid (88.7%), nitrofurantoin (99.2%) and ceftriaxone (99.2%).In the present study E. coli isolates from patients with urinary infection were highly susceptible to fosfomycin. These data suggest that fosfomycin may be a good alternative for fi rst line antimicrobial treatment of uncomplicated low urinary tract infections.
scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.
hi@scite.ai
10624 S. Eastern Ave., Ste. A-614
Henderson, NV 89052, USA
Copyright © 2024 scite LLC. All rights reserved.
Made with 💙 for researchers
Part of the Research Solutions Family.