To report a rare case of erythema multiforme (EM) associated with methotrexate (MTX) with cutaneous and oral manifestations and to compare it to existing cases in which MTX was not used for cancer treatment. A 56-yearsold female, in physical examination skin lesions and multiple oral ulcers associated with pain during manipulation were observed, and underwent treatment for rheumatoid arthritis with Methotrexate 2.5mg. During examination patient-reported that 15 days ago she had undergone a rheumatoid factor examination, doubling the MTX dosage (10mg / day) without doctor's consent. The diagnostic hypothesis of EM. The medical conduct consisted of the suspension of MTX and prescription of a vitamin complex with folinic acid. Local dental therapy for to control oral lesions, pain control and lip hydration was performed using low-level laser therapy (Twin Laser, P: 40mW, T: 50s, DE: 50J / cm), benzydamine hydrochloride spray, purified lanolin for lip dryness, and toothpaste without sodium lauryl sulfate to prevent burning. After 12 days, there was significant remission of oral and skin signs and symptoms, which confirmed the diagnosis was EM due to MTX intoxication. Thorough clinical evaluation and anamnesis favored diagnosis and early multi-professional management provided remission of oral and skin lesions, prevented systemic complications.
O objetivo deste estudo foi realizar uma revisão integrativa para identificar estudos que permitam detectar a calcificações na artéria carótida comum através da radiografia panorâmica digital. Todos os estudos selecionados atenderam aos critérios estabelecidos pela estratégia PICO, e faziam a pergunta: “Qual a prevalência de identificação de ateroma em artéria carótida comum na radiografia panorâmica digital?”. Realizou-se uma estratégia de buscas para cada banco de dados eletrônicos: PubMed, Web of Science, LILACS e, Scopus. Foram encontrados 56 artigos científicos nas bases de dados selecionadas, sendo 5 no PubMed/Medline, 3 no Scopus, 1 no Web of Science e 47 no LILACS, dos quais foram selecionados 12 artigos para a amostra final. Como conclusão, obtivemos que as RP digitais podem auxiliar na identificação precoce da calcificação de ateroma em artéria carótida comum, prevenindo complicações subsequentes.
scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.
hi@scite.ai
10624 S. Eastern Ave., Ste. A-614
Henderson, NV 89052, USA
Copyright © 2024 scite LLC. All rights reserved.
Made with 💙 for researchers
Part of the Research Solutions Family.