A cross-sectional pilot study was conducted in acute leukemia adult patients in order to characterize oral mucosal conditions in acute leukemia, and to analyze their association with certain clinical, nutritional and laboratory parameters. Oral evaluation was performed. Epidemiologic, clinical and laboratory data were considered. Statistical analysis included non-parametric tests and multivariate analysis. A total of 30 patients (60% males) were included; median age of 39 (range 17-62) years old. The median percentage of caloric intake adequacy was 96.8% (range 21.8-205.7%), and the median ideal weight was 117.9% (range 88.2-162.9%). The most common oral mucosal findings were pallor and furred tongue. Leukoedema was seen only in patients <30 years old [OR=1.9 (CI=1.1-3.1); p=0.003]; more cases of fissured tongue [OR=17.1 (CI=1.8-163.8); p=0.005] were seen in subjects >30 years old. Exfoliative cheilitis was more frequent in females [OR=2.7 (CI=1.2-6.1); p=0.02] and in patients with high β-carotene concentrations [Md= 94.5 vs 57.0 µg/dl; (p=0.01)]. Higher rates of diffuse hyperpigmentation were seen (p<0.05) in patients having low vitamin B12 [Me=240 vs 626 pg/ml] and folic acid concentrations [Md=5.8 vs 8.5 ng/ml]; Geographic tongue was found among patients with low serum albumin [Md= 2.7 vs 3.5 g/dl; (p=0.006)] and folic acid [Md=7.9 vs 11.6 ng/mL; (p=0.02)]. Furred tongue was more frequent in patients with low hemoglobin concentration [Md=7.2 vs 8.5 g/dl ;( p=0.01)] and poor oral hygiene [Md=1.1vs 0.7 ;( p=0.04)]. Nutritional depletion was more frequently observed among patients with indentation (p=0.04) and geographic tongue (p=0.03)]. Age, gender and certain micronutrient deficiencies were significantly associated to specific oral mucosal findings in acute leukemia.
La operación de un laboratorio clínico está constituida por la fase preanalítica, analítica y postanalítica, en la medicina de laboratorio todas estas fases son importantes dentro del proceso de un laboratorio; sin embargo, es necesario que se le preste atención a la fase que engloba todos los procedimientos previos al inicio de las pruebas de laboratorio. En este sentido hablamos de la etapa preanalítica donde se lleva a cabo el procedimiento de venopunción. El procedimiento de venopunción se realiza por el flebotomista, quien tiene un rol primario en la colecta de muestras sanguíneas, y debido a que se ha incrementado el número y complejidad de pruebas de laboratorio, la flebotomía se ha convertido en un área especializada. En la etapa preanalítica es donde ocurre la mayoría de los errores de un laboratorio clínico y esto se debe a que el personal que realiza este procedimiento no siempre tiene el conocimiento adecuado y sin este conocimiento el procedimiento de venopunción queda vulnerable representando en más de 70% los errores preanalíticos, afectando el resultado del paciente, el cual requiere para que el médico lleve a cabo el diagnóstico del paciente y con esta acción haya una mejoría en su salud.
scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.
hi@scite.ai
10624 S. Eastern Ave., Ste. A-614
Henderson, NV 89052, USA
Copyright © 2024 scite LLC. All rights reserved.
Made with 💙 for researchers
Part of the Research Solutions Family.