Human skin is commonly described as a particularly dynamic and complex environment, with a physiological balance continuously orchestrated by numerous internal and external factors. Intrinsic aging, exposure to UV radiation and skin pathogens are some of the key players that account for dermatological alterations and ailments. In this regard, this study intended to explore the potential skin-health beneficial properties of a group of molecules belonging to the anthocyanin family: cyanidin- and malvidin-3-O-glucosides and some of their structurally related pigments, resulting in a library of compounds with different structural properties and color hues. The inclusion of both purified compounds and crude extracts provided some insights into their distinctive effects when tested as individual agents or as part of multicomponent mixtures. Overall, most of the compounds were found to reduce biofilm production by S. aureus and P. aeruginosa reference strains, exhibit UV-filter capacity, attenuate the production of reactive oxygen species in human skin keratinocytes and fibroblasts and also showed inhibitory activity of skin-degrading enzymes, in the absence of cytotoxic effects. Carboxypyranocyanidin-3-O-glucoside stood out for its global performance which, combined with its greater structural stability, makes this a particular interesting compound for potential incorporation in topical formulations. Results provide strong evidence of the skin protective effects of these pigments, supporting their further application for cosmeceutical purposes.

Depression is a prevalent and severe medical illness that negatively affects how people feel, think, and act, with estimates pointing towards more than 300 million suffering from depression worldwide. Although effective treatments exist, about 80% of people in low and middle-income countries do not receive therapy. Therefore, technology has become a promising tool to assist in reducing disparities. This study aims to identify and map the available evidence on mobile health applied to depression and clarify key concepts. The authors analyzed clinical trials developed over the last five years. EBSCO and PubMed were searched, and a total of 14 conducted RCTs were selected and reviewed. Despite some limitations regarding dropout rates and several ethical and safety concerns, the mobile mental health future seems promising.

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