A bioactive compound is a product that provides health benefits when consumed, that may include anti-inflammatory, antioxidant activity, ROS and RNS scavenging, specific cytotoxicity, among others. These properties may aid in the prevention and/or mitigation of some chronic diseases 4. Curcumin, known as the Indian gold , has been used to alleviate arrhythmia, and as an aid in the treatment of various illnesses including Alzheimer s, asthma, liver disease, and also as antioxidant, anti-inflammatory, cardioprotective, anticarcinogenic and chemopreventive agent 5 7. Curcumin has been reported to interfere in several mechanisms that control inflammatory responses, among which are: modulation of arachidonic acid metabolism 8 , inhibition of cyclooxygenase 2 COX-2 and lipoxygenase LOX , two enzymes involved in inflammation. COX-2 induces cyto-Abstract: Curcumin is a bioactive compound with proven antioxidant and anti-inflammatory activities, but has low water solubility and dermal absorption. The inflammatory process is considered as the biological response to damage induced by various stimuli. If this process fails to self-regulate, it becomes a potential risk of cancer. The objective of this work was to evaluate the anti-inflammatory activity of curcumin administered to mice with induced atrial edema using two topical vehicles: organogels and O/W-type nanogels at pH 7, Organogels and O/W-type nanogels at pH 7 were prepared, characterized and the antiinflammatory activity was assessed. A histopathological analysis of mouse ears was performed and two gel formulations were selected. Thermograms of organogels indicated that increasing the gelling agent improved the stability of the system. Deformation sweeps confirmed a viscoelastic behavior characteristic of gels in both systems. During the anti-inflammatory activity evaluations, the nanogels demonstrated greater activity (61.8 %) than organogels; Diclofenac ® (2-(2,6-dichloranilino) phenylacetic acid), used as a control medication achieved the highest inhibition (85.4%); however, the drug produced the death of 2 (40%) of the study subjects caused by secondary adverse events. Histopathological analysis confirmed the data.