The aim of this study is to describe the caregivers and physical therapists’ perceptions of telehealth strategies in two cases of infants with Down syndrome during the COVID-19 pandemic in Brazil. Methodology: The physical therapy intervention program was carried out using synchronous and asynchronous methods according to the social context of each family. Results: The telehealth strategies were positively evaluated by caregivers and physical therapists. Conclusion: The study concluded that telehealth has promoted satisfactory results in infants' physiotherapeutic monitoring, and it could be an additional tool for early intervention after the pandemic.
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