BACKGROUNDSeveral reports have indicated higher prevalence of hyperuricemia in patients with Down' syndrome (DS), but gout has been rare. Our objective is to describe an adolescent who was diagnosed with traumatic arthritis and rheumatic fever for four years due to recurrent acute mono/oligo arthritis, whose final diagnosis was gout.
<div>The self-assembly of nanometric structures from molecular building blocks is an effective</div><div>way to make new functional materials for biological and technological applications. In this work</div><div>four symmetrical bolaamphiphiles based on dehydrodipeptides</div><div>(phenylalanyldehydrophenylalanine and tyrosyldehydrophenylalanine) linked through phenyl</div><div>or naphthyl linkers (terephthalic acid and 2,6-naphthalenedicarboxylic acid) were prepared and</div><div>their self-assembly properties studied. The results showed that all compounds with the exception</div><div>of the bolaamphiphile of tyrosyldehydrophenylalanine and 2,6-naphthalene dicarboxylic acid</div><div>gave self-standing hydrogels with critical gelation concentrations of 0.3 and 0.4 wt% using a pH</div><div>trigger. The self-assembly of these hydrogelators was investigated using STEM microscopy,</div><div>which revealed a network of entangled fibres. According to rheology the dehydrodipeptide</div><div>bolaamphiphile hydrogelators are viscoelastic materials with an elastic modulus G’ that falls in</div><div>the range of native tissue (0.37 kPa brain – 4.5 kPa cartilage). In viability and proliferation studies,</div><div>it was found that these compounds were non-toxic towards the human keratinocyte cell line,</div><div>HaCaT. In sustained release assays, we studied the effects of the charge present on the model</div><div>drug compound on the rate of cargo release from the hydrogel networks. Methylene blue (MB),</div><div>methyl orange (MO) and ciprofloxacin were chosen as cationic, anionic and overall neutral cargo,</div><div>respectively. These studies have shown that the hydrogels provide a sustained release of methyl</div><div>orange and ciprofloxacin, while the methylene blue is retained by the hydrogel network.</div>
BACKGROUNDSystemic autoimmune myopathies (SAM) are a group of rare diseases characterized by muscle inflammation. Several types of SAMs are defined with a wide range of different manifestations. This study aimed to describe demographic and clinical characteristics of patients with SAM assisted at a tertiary hospital in the state of Pernambuco.
BACKGROUNDSystemic autoimmune myopathies (SAM) are heterogeneous diseases in which muscle inflammation is a hallmark. Prevalence of obesity has increased worldwide and is an issue of public health. Few studies have evaluated the frequency of obesity and overweight in patients with SAM. This study aimed to determine the presence of obesity or overweight in patients with SAM followed in an outpatient rheumatology clinic at a tertiary hospital in the state of Pernambuco.
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