Objective: To assess the quality of life related to health for heart failure patients and to relate sociodemographic and clinical data. Method: It is an observational and transversal study, with quantitative approach, carried out in a heart failure ambulatory in the state of Pernambuco. Results: In the sample (n=101), there was prevalence of men older than 60 years old, married and professionally inactive. The quality of life related to health, based on the Minnesota Living With Heart Failure Questionnaire, was considered moderate (34.3±21.6), being significantly related to age (p=0.004), functional class (p<0.001), and patients with chagasic cardiopathy (p=0.02). Conclusion: The quality of life in the HF group of chagasic etiology was more compromised, specially in the emotional dimension. It is suggested that studies on the hypothesis that longer ambulatory follow-up improves quality of life and that having Chagas disease interferes negatively with the quality of life of heart failure patients.

RESUMO: O objetivo deste estudo foi caracterizar o perfil clínico e sociodemográfico dos portadores de Insuficiência Cardíaca e descrever o comportamento de autocuidado. Estudo transversal descritivo, com amostra não probabilística de 57 pacientes da enfermaria cardiológica de hospital público do Recife, Brasil, entre maio e setembro de 2016. O autocuidado foi avaliado pela Self-Care of Heart Failure Index versão 6.2, versão brasileira. A idade média dos participantes foi de 62,9 anos; 31 (54,4%) homens; 36 (63,2%) alfabetizados; 26 (45,6%) de etiologia hipertensiva e 30 (52,6%) em classe funcional III. As médias dos escores nas subescalas indicaram autocuidado inadequado (manutenção do autocuidado: 43,3; manejo do autocuidado: 37,5 e confiança do autocuidado: 54,3). Escores mais elevados foram associados com escolaridade, os alfabetizados obtiveram média de 61 pontos (p=0,002). São necessários investimentos para melhorar o autocuidado e a enfermagem pode ter papel relevante nessa melhora. DESCRITORES: Autocuidado; Insuficiência cardíaca; Enfermagem cardiovascular; Qualidade de vida; Doença crônica. AVALIAÇÃO DO AUTOCUIDADO NOS PORTADORES DE INSUFICIÊNCIA CARDÍACA ASSESSMENT OF SELF-CARE IN HEART FAILURE PATIENTSABSTRACT: The objective in this study was to characterize the clinical and sociodemographic profile of heart failure patients and to describe the self-care behavior. Descriptive and cross-sectional study with a non-probabilistic sample of 57 cardiology nursing patients at a public hospital in Recife, Brazil, between May and September 2016. The self-care was assessed by means of the Self-Care of Heart Failure Index version 6.2, Brazilian version. RESUMEN: El objetivo de este estudio fue caracterizar el perfil clínico y sociodemográfico de los portadores de Insuficiencia Cardíaca y describir el comportamiento de autocuidado. Estudio transversal descriptivo, con muestra no probabilística de 57 pacientes de la enfermaría cardiológica de hospital público de Recife, Brasil, entre mayo y septiembre de 2016. El autocuidado fue evaluado por la Self-Care of Heart Failure Index versión 6.2, versión brasileña. El promedio de edad de los participantes fue de 62,9 años; 31 (54,4%) hombres; 36 (63,2%) alfabetizados; 26 (45,6%) de etiología hipertensiva y 30 (52,6%) en clase funcional III. Los promedios de los scores en las subescalas indicaron autocuidado inadecuado (mantenimiento del autocuidado: 43,3; gestión del autocuidado: 37,5 y confianza en el autocuidado: 54,3). Puntuaciones superiores fueron asociadas con escolaridad, los alfabetizados alcanzaron promedio de 61 puntos (p=0,002). Son necesarias inversiones para mejorar el autocuidado y la enfermería puede ter papel relevante en esa mejora.

Immune homeostasis has been suggested to play an important role in the clinical evolution of chronic Chagas disease; however, the immunopathologic factors involved have not been fully elucidated. Therefore, our study aimed to analyse the frequency of CD4 CD25 FoxP3 cells, classic Th17 cells, alternative Th17 cells and IL-17 B cells from peripheral blood of chronic cardiac patients after in vitro stimulation with Trypanosoma cruzi soluble EPI antigen. Patients were selected and classified according to clinical evaluation of cardiac involvement: mild, B1 (CARD1) (n = 20) and severe, C (CARD2) (n = 11). Patients with the indeterminate form of CD were included as the control group A (IND) (n = 17). Blood samples were collected and cultured in the presence of EPI antigen. Cells frequency and median fluorescence intensity (MFI) were obtained by flow cytometry. Our results showed that only CD4 CD25 FoxP3 , CD4 CD25 FoxP3 , CD4 IL-17 IFN-γ and CD4 IL-17 IFN-γ cells are more frequent in patients with severe cardiac disease and correlate with worse global cardiac function. However, while indeterminate patients demonstrated a positive correlation between CD4 CD25 FoxP3 and CD4 IL-17 IFN-γ Th17 cells, this relationship was not observed in cardiac patients. IL-17 expression by Th17 cells and B cells correlated with disease progression. Altogether our results suggest that the clinical progression of Chagas cardiomyopathy involves worsening of inflammation and impairment of immunoregulatory mechanisms.

Background: Recently, a new HF entity, with LVEF between 40-49%, was presented to comprehend and seek better therapy for HF with preserved LVEF (HFpEF) and borderline, in the means that HF with reduced LVEF (HFrEF) already has well-defined therapy in the literature. Objective: To compare the clinical-therapeutic profile of patients with HF with mid-range LVEF (HFmrEF) with HFpEF and HFrEF and to verify predictors of hospital mortality. Method: Historical cohort of patients admitted with decompensated HF at a supplementary hospital in Recife/ PE between April/2007-August/2017, stratified by LVEF (< 40%/40-49/≥ 50%), based on the guideline of the European Society of Cardiology (ESC) 2016. The groups were compared and Logistic Regression was used to identify predictors of independent risk for in-hospital death. Results: A sample of 493 patients, most with HFrEF (43%), HFpEF (30%) and HFmrEF (26%). Average age of 73 (± 14) years, 59% men. Hospital mortality 14%, readmission within 30 days 19%. In therapeutics, it presented statistical significance among the 3 groups, spironolactone, in HFrEF patients. Hospital death and readmission within 30 days did not make difference. In the HFmrEF group, factors independently associated with death were: valve disease (OR: 4.17,

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