In NF1, Lnfs are common, mainly in larger tumors and women. All cutaneous NF1-neurofibromas express leptin. It is unknown if the expression of leptin accounts for the lipomatous variant, but it may have a role in the pathogenesis of cutaneous neurofibroma.
Lhermitte-Duclos disease (dysplastic gangliocytoma of the cerebellum) is a rare benign cerebellar mass of unknown etiology which is characterized by enlargement of the cerebellar folia 1,2 . Despite the controversy regarding its pathogenesis, imaging and histopathological findings are rather typical 1,2,3,4 . A 17-year-old female presented with a 2-year history of progressive headaches and gait imbalance. Cranial CT revealed a cerebellar expanding mass and hydrocephalus. The patient underwent shunt insertion and was referred to our department for treatment. MRI demonstrated a non-enhancing left hemisphere cerebellar tumor (Figure 1) which was subtotally resected during surgical procedure. Figure 2 shows the histological findings. Postoperative course was uneventful.
Os autores fizeram uma revisão sistemática sobre a interdisciplinaridade e o ensino médico no Brasil após 2014, quando a Diretriz Curricular Nacional tornou obrigatório adotar uma perspectiva interdisciplinar. Evidenciou-se que há poucos estudos que fazem efetivamente uma discussão qualificada da temática em questão o que mostra que aponta ausência de subsídios na literatura para dar elementos para refletir as mudanças que deverão ocorrer na estrutura dos cursos de medicina no Brasil. Os artigos, apesar de citar a interdisciplinaridade não a conceituam nem discutem o que configura uma lacuna de conhecimento que demanda estudos e publicações.
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