Two cases of intrahepatic biliary cystadenoma, a rare tumor with malignant potential, are discussed. The sonographic, computed tomographic (CT), and magnetic resonance imaging (MRI) findings are presented together with clinical features of this entity and a brief review of the pertinent literature.
Decreased expression of pSMAD1 in the cystic epithelium with further reduction in the adenomatous area, and increase in COX-2 expression within polyps from the BMPR1A heterozygote, suggest a potential mechanism for adenomatous pathogenesis in these hamartomatous polyps. This may imply that COX-2 inhibitors could be a means for chemoprevention in this syndrome.
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