Introduction: COVID-19 is an infectious disease caused by the novel coronavirus SARS-CoV-2 (severe acute respiratory syndrome coronavirus 2). World Health Organization declares COVID-19 a global pandemic on the 11th of March 2020. Objective: Considering that there is no successful treatment to cure the disease, it is highly important to find a way to predict the severity of the infection in order to improve healthcare strategies. Some serum biomarkers are linked to the infection and evolution of COVID-19. Discussions and conclusions: Among other biomarkers, C Reactive Protein (CRP) is useful in anticipating the poor outcome in COVID patients. For every 1 unit increase in CRP levels, the risk of developing a severe form of COVID-19 increases by 5%. Besides its predictive role, CRP guides the doctors in taking the decision of administrating dexamethasone to decrease the systemic inflammation induced by SARS-CoV-2. Rezumat Introducere: COVID-19 este o boală infecțioasă cauzată de noul coronavirus SARS-CoV-2 (coronavirus producător de sindrom respirator acut sever). Organizația Mondială a Sănătății declară pandemie de COVID-19 pe 11 Martie 2020. Obiectiv: Având în vedere că nu exită un tratament curativ pentru această boală, este important să se descopere o modalitate de a prezice evoluția cu potențial sever, cu scopul de a îmbunătăți strategiile salvatoare de viață. Anumiți markeri serici se corelează cu infectarea și evoluția COVID-19. Discuții și concluzii: Printre alți biomarkeri serici, se distinge proteina C reactivă (PCR) care ajută la anticiparea evoluției nefavorabile a pacienților COVID. Pentru fiecare unitate PCR crescută, riscul de a dezvolta o formă severă crește cu 5%. Pe lângă rolul său predictiv, PCR ajută medicii să selecționeze cazurile ce ar beneficia de tratamentul cu dexametazonă, menit să combată inflamația sistemică indusă de SARS-CoV-2.
The aim of the retrospective study was the analysis of antibiotic resistance patterns of bacteria involved in urinary tract infections in patients hospitalized during 2019 in the Intensive Care Unit of the Clinical County Emergency Hospital Brasov. The main bacteria involved were Escherichia coli (38,68%), Klebsiella species (23,69%) and Enterococcus species (15,68%). Various degrees of resistance to the tested antibiotics were observed. ESBL strains were detected at Escherichia coli (20,72.%) and Klebsiella species (10,29%). Carbapenem resistant strains were detected at Klebsiella spp. (48,48%), P. aeruginosa (56,25%) and Acinetobacter spp. (85,71%). MRSA, VRE and HLAR strains were also detected in the studied group.
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