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Predictive biomarkers of trabectedin represents an unmet need in advanced soft-tissue sarcomas (STS). DNA damage repair (DDR) genes, involved in homologous recombination or nucleotide excision repair, had been previously described as biomarkers of trabectedin resistance or sensitivity, respectively. The majority of these studies only focused on specific factors (ERCC1, ERCC5 and BRCA1) and did not evaluate several other DDR-related genes that could have a

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Montel V, GaultierA, Lester RD, Campana WM, Gonias SL. The LRP1 regulates cancer cell survival and metastasis development. Cancer Res. 2007; 67; 9817-9824. 3. Song H, Li Y, Lee J, Schwartz AL, Bu G. Low-density lipoprotein receptor-related protein 1 promotes cancer cell migration and invasion by inducing the expression of matrix metalloproteinases 2 and 9. Cancer Res. 2009; 69; 879-886. 4. Fayard B, Bianchi F, Dey J et al. The serine protease inhibitor protease nexin-1 controls mammary cancer metastasis through LRP-1-mediated MMP-9 expression. Cancer Res. 2009; 69; 5690-5698. 5. Catasus L, Gallardo A, Llorente-Cortes V et al. Low density lipoprotein receptor-related protein 1 (LRP-1) is associated with proliferation and invasiveness in Her-2 ⁄ neu and triple negative breast carcinomas. Hum. Pathol. 2011: [E-pub ahead of print] DOI: 10.1016/j.humpath.2011.01.011. 6. Dedieu S, Langlois B. LRP-1: a new modulator of cytoskeleton dynamics and adhesive complex turnover in cancer cells. Cell Adh. Migr. 2008; 2; 77-80. 7. Langlois B, Perrot G, Schneider C et al. LRP-1 promotes cancer cell invasion by supporting ERK and inhibiting JNK signaling pathways. PLoS ONE 2010; 5; e11584. 8. Dedieu S, Langlois B, Devy J et al. LRP-1 silencing prevents malignant cell invasion despite increased pericellular proteolytic activities.

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