Aim: To test the protective effect of a commercially available mixture of hyaluronic acid, chondroitin sulfate and poloxamer 407 on the damage caused by the exposure of esophageal mucosa to button batteries in an animal model.
Methods: Experimental study. 60 porcine esophageal samples distributed in three groups: control (CG), exposure (EG) and exposure-protection (EPG). In EG and EPG, one CR2032 button battery per sample was inserted, both were subdivided into 2h, 4h, 6h and 24h exposure subgroups, with subsequent battery removal. EPG samples were irrigated with the solution 1h after battery exposure. Esophageal pH and final voltage of the battery were measured.
Results: pH in CG remained stable. No significant differences in pH at one hour were found between EG and EPG. In EPG, the pH of the mucosa exposed to the anode was lower than in GE at 2h (12.44 vs 11.89, p=0.203) and 4h (13.78 vs 11.77, p<0.0001). In the cathode pH was significantly higher in EG at 2h (2.5 vs 4.11, p<0.0001), 4h (2.33 vs 4.78, p<0.0001) and 6h (2.17 vs 2.91, p<0.0001). Significant voltage reduction at 1h was found in EG compared to EPG (0.48V vs 1.08V, p=0.004).
Conclusion: Exposure to hyaluronic acid solution buffers the acidification on the side exposed to the cathode and basification on the anode. This effect can be maintained up to 3-5h, even after stopping its application. Our results suggest that a solution containing hyaluronic acid could be used as an esophageal protector after accidental ingestion of button batteries.
scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.