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A simple and rapid procedure based on solid phase disk extraction (SPDE), adsorption chromatography on acidified silica gel and GC-MS analysis was developed for the determination of 8 organochlorine pesticides and 19 PCB congeners in human milk By using the SPDE procedure, a high throughput and parallel sample processing could be achieved. Method variables were optimized on whole cow's milk (3.5% fat) fortified at levels close to concentrations found in human milk Recoveries of target analytes were acceptable and ranged from 69 to 102% and 86 to 120% forwhole and skimmed milk, respectively. By the use of I',,vo stage clean-up and narrow bore capillary columns, detection limits as low as 20 pg mL lcould be obtained. The method was used for the determination of organochlorine pollutants in human milk from 19 individuals from Romania. The concentrations of PCBs were low, whereas those of organochlorine pesticides were higher than thevalues reported from other European countries.

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