Novel salts of the antibiotic sulphamethoxazole were obtained and characterized, effectively showing enhanced solubility.

The vitamins analyzed showed relevant in vitro inhibitory potential over the activities induced by Bothrops venoms, suggesting their interaction with toxins belonging to the phospholipase A2, protease, and lectin classes. The results can aid further research in clarifying the possible mechanisms of interaction between vitamins and snake enzymes.

Two sulfamethoxazole polymorphs (form I and II) have been studied. The form II → form I transformation is observed via milling and dissolution in acetonitrile. A phase transition mechanism is proposed based on their supramolecular geometries.

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