To determine, in patients with coronavirus disease 2019 (COVID-19) infection, the associations of pulmonary embolism (PE) with mortality and risk factors for PE as well as the therapeutic benefit of anticoagulant prophylaxis. Embase, PubMed, Cochrane controlled trials register, and Web of Science databases were searched from inception to October 10, 2020. We included all published trials on PE in patients diagnosed with COVID-19 with eligibility of the trials assessed following the PRISMA guidelines. Sixteen clinical trials with 5826 patients were eligible. There were significant associations of PE with the male gender [odd ratio (OR) = 1.59, 95% CI 1.28–1.97], mechanical ventilation (OR = 3.71, 95% CI 2.57–5.36), intensive care unit admission (OR = 2.99, 95% CI 2.11–4.23), circulating D-dimer [mean difference (MD) = 5.04 µg/mL, 95% CI 3.67–6.42) and CRP (MD = 1.97 mg/dL, 95% CI 0.58– 3.35) concentrations without significant correlation between PE and mortality (OR = 1.31, 95% CI 0.82–2.08) as well as other parameters or comorbidities. After omitting one trial with strict patient selection criteria for anticoagulant prophylaxis, significant prophylactic benefit was noted (OR = 0.31, 95% CI 0.1–0.91). Our findings identified the risk factors associated with PE in COVID-19 patients and supported the therapeutic benefit of anticoagulant prophylaxis against PE in this patient population.

Palabras clave: intestino delgado; técnicas de sutura; anastomosis quirúrgica; dehiscencia de la herida operatoria; fístula intestinal; desnutrición proteico-calórica.

Abstract:The link between properties of a system at equilibrium, in particular free energy difference, to the fluctuations in the work performed during non-equilibrium process is called Crooks relation. This relation, which is a measure of the grade of irreversibility of a process, was elegantly derived based on the equations of motion for a set of particles along with the formal solution of the evolution equation using a distribution function, both solved in a classical and a stochastic way. This technical note, reports on a simple derivation of Crooks formula based on the energy balance and entropy generation in a system undergoing a process in which fluctuations are not neglected

This work describes the nonlinear Thomson effect produced by a transient current source powering a thermoelectric cooler. The electric effect of the capacitive impedance in the semiconductors was considered in the equations as a novelty term that naturally appears by solving the Boltzmann equation to find the mathematical form of the current density. Thus, considering the new term and heath energy balances, a one-dimensional mathematical model for a thermoelectric cooler (TEC) powered by a time-dependent current was developed, finding a new nonlinear Thomson effect in the heath transfer equations. To evaluate the impact of the nonlinear effect on the thermodynamic behavior of the thermoelectric cooler, a continuous, sinusoidal and square-pulse current conditions were simulated. The temperature profile, temporal evolution, and the effective coefficient of performance (COP) were calculated. The results revealed a new thermoelectric heat transfer in addition to the Thomson flow created by virtual junctions throughout the semiconductors caused by the instantaneous change of current. This fact was evidenced by three results: the shifting of the temperature mean value due to the peak current change 0.45 A is 1.68 K 1.68\hspace{0.1667em}\mathrm{K} and 2.56 K 2.56\hspace{0.1667em}\mathrm{K} to sinusoidal and square current supplies, respectively; it was determined that a TEC powered by a square-pulse current signal had greater effective efficacy, having more pronounced cold side supercooling temperature peaks compared to those powered by a constant sinusoidal current signal.

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Introducción. La hipocalcemia es la complicación más frecuente de la tiroidectomía. La profilaxis con calcio/ calcitriol es una alternativa costo-efectiva, sencilla y expedita para disminuir esta situación, sin alterar la función paratiroidea residual. Lo que no está claro es si hay superioridad de una dosis frente a otra, por lo que el objetivo de este estudio fue evaluar el comportamiento entre diferentes esquemas de profilaxis para hipocalcemia. Métodos. Estudio de cohorte retrospectivo de adultos operados en un hospital de cuarto nivel, entre febrero de 2017 y diciembre de 2020. Se calculó la tasa de síntomas, la hipocalcemia e hipercalcemia bioquímica en el control postquirúrgico durante las siguientes dos semanas. Se hizo análisis bivariado y multivariado entre dosis de calcio/ calcitriol, otros factores asociados y los desenlaces mencionados. Resultados. Se incluyeron 967 pacientes. El 10 % presentaron síntomas. No hubo diferencias significativas en el calcio sérico del control posquirúrgico entre los grupos con distintas dosis de calcio. La dosis de carbonato de calcio >3600 mg/día y el calcio en las primeras 24 horas de cirugía se asociaron a la presencia de síntomas. La dosis de calcitriol  <1 mcg/día y el bocio aumentaron el riesgo de hipocalcemia bioquímica, mientras que la dosis de 1,5 mcg/día lo disminuyó. Ninguna variable evaluada se asoció a hipercalcemia bioquímica. Conclusiones. Teniendo en cuenta los resultados observados con las dosis de calcio y calcitriol, sugerimos iniciar la profilaxis con un esquema de 3600 mg/día de carbonato de calcio y 1,5 mcg/día de calcitriol. Sin embargo, esta dosis debe modificarse en situaciones como bocio o calcio sérico temprano anormal, que fueron las variables asociadas a mayor riesgo en nuestro estudio.

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