SummaryBackground: Developing countries need telemedicine applications that help in many situations, when physicians are a small number with respect to the population, when specialized physicians are not available, when patients and physicians in rural villages need assistance in the delivery of health care. Moreover, the requirements of telemedicine applications for developing countries are somewhat more demanding than for developed countries. Indeed, further social, organizational, and technical aspects need to be considered for successful telemedicine applications in developing countries. Objective: We consider all the major projects in telemedicine, devoted to developing countries, as described by the proper scientific literature. On the basis of such literature, we want to define a specific taxonomy that allows a proper classification and a fast overview of telemedicine projects in developing countries. Moreover, by considering both the literature and some recent direct experiences, we want to complete such overview by discussing some design issues to be taken into consideration when developing telemedicine software systems. Methods: We considered and reviewed the major conferences and journals in depth, and looked for reports on the telemedicine projects. Results: We provide the reader with a survey of the main projects and systems, from which we derived a taxonomy of features of telemedicine systems for developing countries. We also propose and discuss some classification criteria for design issues, based on the lessons learned in this research area. Conclusions: We highlight some challenges and recommendations to be considered when designing a telemedicine system for developing countries.

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A large volume of research in temporal data mining is focusing on discovering temporal rules from time-stamped data. The majority of the methods proposed so far have been mainly devoted to the mining of temporal rules which describe relationships between data sequences or instantaneous events and do not consider the presence of complex temporal patterns into the dataset. Such complex patterns, such as trends or up and down behaviors, are often very interesting for the users. In this paper we propose a new kind of temporal association rule and the related extraction algorithm; the learned rules involve complex temporal patterns in both their antecedent and consequent. Within our proposed approach, the user defines a set of complex patterns of interest that constitute the basis for the construction of the temporal rule; such complex patterns are represented and retrieved in the data through the formalism of knowledge-based Temporal Abstractions. An Apriori-like algorithm looks then for meaningful temporal relationships (in particular, precedence temporal relationships) among the complex patterns of interest. The paper presents the results obtained by the rule extraction algorithm on a simulated dataset and on two different datasets related to biomedical applications: the first one concerns the analysis of time series coming from the monitoring of different clinical variables during hemodialysis sessions, while the other one deals with the biological problem of inferring relationships between genes from DNA microarray data.

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Workflow technology has emerged as one of the leading technologies in modeling, redesigning, and executing business processes.\ud The management of temporal aspects in the definition of a workflow process has been considered only recently in the literature.\ud Currently available workflow management systems (WfMS) and research prototypes offer a very limited support for the definition, detection, and management of temporal constraints over business processes.\ud In this paper, we propose a new advanced workflow conceptual model for expressing time constraints in business processes and we present a general technique to check different levels of temporal consistency for workflow schemata at process design time: since a time constraint can be satisfied in different ways, we propose a classification of temporal workflows according to the way time constraints are satisfied.\ud Such classification can be used to successfully manage flexible workflows at run time

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