Responsible innovation has always been an important issue in discourses addressing the major challenges faced by humankind in terms of natural resource degradation, climate change, economic progress and societal well-being. However, its integration into industry is still in its infancy, and even more so when it comes to small and medium-sized enterprises (SMEs). The aim of this research is to use a systematic literature review to develop a conceptual model for responsible innovation and its relationship with SME performance, in connection with sustainable innovation and corporate social responsibility practices. A bibliometric analysis of 102 articles collected between 2000 and April 2020 from the Web of Science database was used, in addition to the systematic literature review using the Gephi and NVivo software. The study presents an overview of the articles, authors, and most influential journals and research clusters identified, and provides a solid conceptual framework to be applied in this field and in the context of SMEs.