Both dl-Delta(8)- and dl-Delta(9)-tetrahydrocannabinol produced marked alterations of behavior in rhesus and squirrel monkeys. Squirrel monkeys appeared to have visual hallucinations. Continuous avoidance behavior of squirrel monkeys was stimulated by both drugs, but high doses of dl-Delta(9)-tetrahydrocannabinol also caused depression after the stimulant phase. Complex behavior involving memory and visual discrimination in rhesus monkeys was markedly disrupted by both drugs.
An automatically controlled, delayed matching procedure in which the duration of the delay interval was varied according to a self-adjusting procedure was developed. The range of delay intervals which could be presented to Ss was 1-105 sec., but particular delays presented in any 1 session were a function of S's responses. Correct matching responses increased the duration of the delay interval, and incorrect matching responses decreased the delay interval. Using this procedure, limit of delay and fluctuation of this limit over time was determined in 4 rhesus monkeys. During a given session average limit of delay was 45 sec. with a range of 30-70 sec.
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