Abstract— The photodynamic binding of psoralen to DNA and RNA was shown using different methods. This binding was found to be mainly located either at thymine or uracil. The concentration and pH dependancy was studied. The photoproduct obtained with uridine was isolated paper chromatographically and was split into initial components photochemically.
The results bring an evidence that psoralen with its 3,4‐double bond is able to form a cyclic derivative with the C6‐C6 doble bond of thymine or uracil.
Philodiene wie Derivate des Maleinsaurcanhydrids oder Inden und cyclische Diene wie Furan lassen sich durch photosensibilisierte Cyclo-Addition nach dem Prinzip der rein biradikalischen Substrat-Ubertragung zu Cyclobutanderivaten vereinigen.Die photosensibilisierten Cyclodimerisationen des Cumarins 1) und des Acenaphthylens 2.3) sind rein x-addierende Dimerisationen von Philodienen wie A und B, die nach dem Prinzip der photosensibilisierten Substrat-&xtragung4) zu Cyclobutanderivaten AB fuhren.
Cumarin bildet unsensibilisiert das Photodimere IIa, sensibilisiert die Photodimeren IIb und IIc Beide Reaktionen haben keine gemeinsamen Zwischenprodukte.
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