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The density of a2-adrenoceptors, using 3H-idazoxan as the radioligand, was determined by quantitative lUtoradiography in the locus coeruleus and in 13 noradrenergic projection fields following chronic Idministration of drugs acting on noradrenergic and/or StTOtonergic neurons. Protriptyline, an inhibitor of the JlPfake of norepinephrine, and mianserin, an al'lUirenoceptor antagonist, reduced the binding of lH·idazoxan only in the locus coeruleus. Phenelzine, an inhibitor of both type A and type B monoamine oxidase (MAO), reduced the binding of 3H-idazoxan in the locus CM'II leus and in several areas with noradrenergic innervation from tegmental cell bodies. Clorgyline, a stltctive inhibitor of type A MAO, had no effect. Of the trro selective inhibitors of serotonin uptake, citalopram lEY WORDS: a2-adrenoceptors; 3H-Idazoxan; Locus uxruleus: Antidepressants

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