Background: Mother and fetal Doppler ultrasound during pregnancy is an established and safe tool for quantitative analysis of the utero-placental and the fetoplacental blood flow and seems to be affected by Ethnic hetérogenicity. Objective. To establish normative data for the resistive index of Uterine arteries, Umbilical artery and middle cerebral artery of Cameroonian pregnant women in the second half of pregnancy using multiples of the median and percentile reference range.Methods. We conducted a cross-sectional study on 93 low risk singleton gestation women aged above 18 years between 28 and 39 weeks of gestation in two hospitals in Cameroon during 7 months. We seek for resistive index (RI) of both left and right uterine arteries (LUt and RUt), Umbilical artery (UmA) and Middle cerebral artery (MCA). We also estimated the gestational age (GA), the mother age, the fetal weight (EFW) and the cerebro – placental ration (CPR).Pearson's correlation analysis of the relationship between these RI and selected maternal parameters was done. Regression modeling across gestational age was performed to obtain the reference values and normogram curve with values ranged at 5 and 95th percentiles. P < 0.05 was considered statistically significant.Results. The mean GA and EFW was 33.5 +/- 2.92 weeks (médian of 34) and 2337.5 +/- 734 g respectively. The means RI value of target vessels were 0.55 +/- 0.077; 0.76 +/- 0.071 ; 0.48 +/- 0.077 and 0.46 +/-0.087 for UmA, McA, RUt and LUt with extremes values of des 0.38 to 0.77 ; 0.49 to 0.87; 0.30 to 0.70 and 0.29 to 0.69 respectively. Only UmA RI and CPR values had shown correlations with GA (r= - 0.338, p≤0.01 and r=0.314; p≤0.001) and EFW (r=-0.445, p≤0.001 and r=0.234; p = 0.02). No difference between LUt and RUt RI values was found. The nomogram curve for UmA, McA, RUt and LUt value revealed a general low RI values of in our sample.Conclusions. Fetal Doppler should carefully interpreted according to general low RI values during low risk singleton pregnancy shown by this study. The generated 5and 95th percentiles RI values curves for each target vessel could be useful in that way.Trial registration:N°431/UY1/FMSB/VDRC/CSD du 24 mai 2017 by the Institutional Review Board at the faculty of Medicine and Biomedical Sciences of University of Yaoundé 1.
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