-With the purpose of studying data on spontaneous customary changes in diabetic rats, we induced diabetes in 28 Wistar rats with streptozotocin. The animals were observed for 27 weeks in an attempt to characterize spontaneous customary changes that could suggest signs of chronic pain. Morphine, as a central-acting potent analgesic and its specific antagonist naloxone, were used. Our results evidenced in the animals a clinical syndrome similar to human diabetes. Long-term customary analysis revealed a significant (p<0.05) increase of scratching and resting/sleeping behaviors, but diminished motor, eating and grooming customs. Moreover, the thermal tests revealed hyperalgesia in 43% of the animals, what may corroborate the meaning of scratching as a sign of pain. Pharmacological tests with morphine showed a significant (p<0.05) inhibition of scratch, with concomitant increase of motor and eating activities and diminished rest/sleep capacity. Naloxone antagonized the effects induced by morphine. Such results suggest that these animals exhibit evoked behavior of hyperalgesia and that scratch may possibly be a spontaneous manifestation of chronic pain also in Wistar rats with this experimental model of painful diabetic neuropathy.KEY WORDS: chronic pain, painful neuropathy, experimental diabetic neuropathy, spontaneous scratching behavior, morphine, naloxone, long-term profile. Mudança do comportamento de ratos Wistar no modelo experimental de neuropatia diabética dolorosaRESUMO -Com o objetivo de estudar dados sobre mudança de comportamento em ratos com neuropatia diabética dolorosa, induzimos diabetes em 28 ratos Wistar com estreptozotocina. Os animais foram então observados ao longo de 27 semanas com o propósito de caracterizar mudanças espontâneas em seus hábitos que pudessem sugerir sinais de dor crônica. Morfina como um potente analgésico de ação central e seu antagonista específico naloxona foram utilizados. Nossos resultados evidenciaram nos animais uma síndrome clínica semelhante ao diabetes humano (poliúria, catarata, perda de peso, neuropatia sensitivo-motora de predomínio distal). A análise comportamental revelou aumento dos comportamentos de coçar-se e descansar/dormir, e diminuição das atividades motoras e hábitos de comer e limpar-se. Além disso, os testes térmicos revelaram sinais de hiperalgesia em 43% desses animais, o que corrobora o significado de coçar-se como sinal de dor. Os testes farmacológicos com morfina evidenciaram inibição significativa (p<0,05) no hábito de coçar-se, com aumento recíproco das atividades motoras e de alimentar-se, e diminuição do tempo de descansar/dormir. A naloxona antagonizou os efeitos da morfina. Tais resultados sugerem que esses animais exibiram comportamento evocado de hiperalgesia e que o hábito de coçar-se é possivelmente uma manifestação espontânea de dor crônica nesse modelo de neuropatia diabética dolorosa em ratos Wistar. PALAVRAS-CHAVE: dor crônica, neuropatia dolorosa, neuropatia diabética experimental, comportamento espontâneo de coçar-se, morfin...
-HTLV-I infection and associated myelopathy has been reproduced experimentally in vitro and in vivo and these studies have shown the possibility of creating several lines of infective cells and of detecting minor and major clinical expressions of HTLV-I associated myelopathy in rabbits and rats.
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