Drug-induced phospholipidosis (PL) is an excessive accumulation of phospholipids and drug in lysosomes. Phospholipidosis signals a change in cell membrane integrity and accumulation of intracellular drug or metabolite in tissues. The sensitivity and susceptibility of preclinical models to detect PL vary with therapeutic agents, and PL is expected to be reversible after discontinuation of drug treatment. The prevailing scientific opinion is that PL by itself is not adverse; however, some regulatory authorities consider PL to be adverse because a small number of chemicals are able to cause PL and concurrent organ toxicity. Until a greater understanding of PL emerges, a well-thought-out risk management strategy for PL will increase confidence in safety and improve selection and development of new drugs. This paper provides a tiered approach to risk management of drug-induced PL. It begins with use of in silico and in vitro tools to design and select compounds with reduced potential to produce PL. Early in vivo studies in two species are used to better characterize potential for toxicity and PL. Finally, routine risk management tools (i.e., translational biomarkers, assessment of reversibility) are used to support confidence in safety of compounds that induce PL in animals.

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With increasing concern for the environment, there has been a strong interest in ecotourism in Hong Kong, culminating in the opening of the Hong Kong Wetland Park (HKWP) by the local government in 2005. Since the HKWP uses various on-site interpretive services to help to convey education and conservation messages on environmental issues, through the use of a recent survey this paper aims to examine and analyze their use and effectiveness in achieving the intended purpose. The questionnaire was completed by 206 visitors and reveals that experiential facilities, interpretive signs and exhibition materials are the three most frequently used services. Although guided interpretive tours have received the highest satisfaction rating and are considered the most effective means of conveying educational and conservation messages, the survey found that this service is still unknown to many visitors and more public exposure is recommended. Interestingly, in terms of the goal of the wetland park's ability to convey an educational message to its patrons, the survey has also found a significant difference in success rate between visitors with a desire for knowledge and visitors merely enjoying a leisurely activity.

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