The aim of this study was to investigate the relationships between work-home/home-work interaction, psychological conditions and employee engagement. A cross-sectional survey was used. The participants were 292 employees of a uranium mine in Namibia residing in towns distant from their workplace. The following measuring instruments were used: Survey Work-Home Interaction -Nijmegen, Psychological Conditions Scale and Work Engagement Scale. Positive work-home interaction and negative home-work interaction had direct positive and negative effects on psychological meaningfulness and psychological availability respectively. Psychological meaningfulness, psychological availability, positive work-home interaction and positive home-work interaction had direct effects on employee engagement. An analysis of the indirect effects showed that positive work-home interaction affected employee engagement via experiences of psychological meaningfulness and psychological availability. Negative home-work interaction affected employee engagement negatively via low psychological meaningfulness and low psychological availability. Implementing policies to promote meaningfulness and availability at work, to build positive workhome interaction and to protect employees against negative home-work interference, will contribute to personal engagement at work.