Public reporting burden for this collection of information is estimated to average 1 hour per response, including the time for reviewing instructions, searching existing data sources, gathering and maintaining the data needed, and completing and reviewing this collection of information. Send comments regarding this burden estimate or any other aspect of this collection of information, including suggestions for reducing this burden to Department of Defense, Washington Headquarters Services, Directorate for Information Spinal cord injury is a devastating and debilitation condition that can induce depression and anxiety in the acute and chronic setting. There is general agreement in the medical community that these psychological health issues should be treated, mainly with administration of antidepressant medications. When considering which antidepressant drug to use, many physicians give venlafaxine, yet what remains unclear is the effect of this therapy on plasticity, functional rehabilitation and longterm psychological health after SCI. We are, therefore, using a rat model of SCI to study each of these variables. We report the exercise rehabilitation after SCI induced increases in hind limb locomotor recovery with no significant changes in allodynia or lower urinary tract function. Also, exercise rehabilitation induced an increase in immobility time as measured in the Porsolt forced swim, which was found to be related to swimming ability. Thus, we have found that exercise rehabilitation increases functional recovery and on-going studies will evaluate the effect of venlafaxine on this improvement.
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