Equine herpesvirus 1 isolates from a 2021 outbreak of neurologic disease in Europe have a mutation, A713G, in open reading frame 11 not detected in 249 other sequences from equine herpesvirus 1 isolates. This single-nucleotide polymorphism could help identify horses infected with the virus strain linked to this outbreak.
Background: Equine herpesvirus type 1 (EHV-1) induces respiratory infection, abortion, and neurologic disease with significant impact.Objectives: Deletion of the virulence factor-encoding open reading frame 2 from the neuropathogenic EHV-1 strain Ab4 yielded a new vaccine candidate, Ab4ΔORF2, which was analysed for safety and efficacy in vivo.
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