Due
to the high reactivity of alkoxyl (RO·) radicals and their
propensity to easily undergo β-scission or Hydrogen Atom Transfer
(HAT) reactions, intermolecular alkoxylations involving RO· radicals
are barely described. We report herein for the first time the efficient
intermolecular trapping of alkoxyl radicals by silyl enol ethers.
This photoredox-mediated protocol enables the introduction of both
structurally simple and more complex alkoxy groups into a wide range
of ketones and amides.
We report herein a general and highly selective γ-functionalization protocol under visible light irradiation. This mild radical approach enables to expand the scope of application to unbiased enals and to...
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