The aim of this study was to characterize the sociodemographic profile and changes in the metabolic profile of women living with HIV/AIDS. A cross-sectional study of a retrospective cohort was conducted in women with HIV/AIDS treated at the Specialized Care Service (SCS) in Ponta Grossa, Paraná. Between January/2008 and December/2017, data from 111 women were included. The variables of interest in the study were: Sociodemographic, such as gender, age at the date of diagnosis, color, education, marital status, sexual behavior and mode of transmission of HIV; and metabolic, collected in 2008 and 2017, such as metabolic profile, CD4 counting, viral load and treatment followed. The comparison between periods was evaluated with the tests paired T, Wilcoxom or McNemar depending on the characteristic of the variable. The highest prevalence was in the age group of 30-39 years, in which 80.2% declared themselves white, 60.4% with incomplete elementary school and 61.3% were housewives, 42.3% were married, 91% reported that the mode of transmission was sexual and 90.1% declared themselves heterosexual. Weight increased by 4.9% (p < 0.001), cholesterol, HDL and glycemia increased slightly (p = 0.126, p = 0.180 and p = 0.108), respectively, triglycerides had a slight decrease (p = 0.866) and blood pressure did not change significantly. Cd4 increased, on average, 41.1% in patients (p < 0.001). Viral load decreased, on average, 93.4% (p < 0.001). These results show that there was an increase in weight and other factors considered at risk for the development of metabolic syndrome and cardiovascular events.