The prevalence of distance education utilizing asynchronous instruction has increased in recent years. Asynchronous instruction differs from the more common synchronous instruction in that learners primarily contact the lessons and educational materials on their own rather than with a live instructor. Though not without its limitations, asynchronous instruction offers a variety of advantages that can make instruction more efficient, produce better outcomes, and increase accessibility to a greater variety of learners if created using known principles of effective instructional design. Though many platforms exist for creating asynchronous instruction, these are often accompanied by barriers to their widespread use. A potential cost-effective and flexible alternative to these is Microsoft® PowerPoint TM . The present report serves as a guide for creating interactive and responsive asynchronous instructional sequences with PowerPoint for Microsoft 365® using principles and procedures derived from programmed instruction (Skinner, 1968 ). Ideas for additional response types are also provided, as are the limitations of designing instructional sequences with this software. Previous papers on the use of PowerPoint as an instructional tool have been primarily geared towards instruction for young learners or learners with autism. As such, the present article expands on the use of PowerPoint specifically to higher education.