We report here on a method for the determination of urine iodine by ICP-MS. The method proved to be fast, reliable and precise (within batch CVs v2.5%) and to have a low limit of detection (0.000 38 mmol L 21 ). Iodine was determined in a total of 379 urine samples from 86 healthy pregnant women who gave samples at intervals of 4 weeks from 16 weeks pregnancy to 10 weeks post-partum. Fifty-®ve control urine samples were analysed from age-matched non-pregnant females. Iodine excretion (mmol of iodine per mol of creatinine) increased signi®cantly from 28±40 weeks of pregnancy (pv0.05), returning to non-pregnant control levels by 10 weeks post-partum. This study con®rms the ability of our ICP-MS method to analyse large numbers of patient samples with the speed and performance acceptable for a routine assay.
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