Highlights d A linear epitope landscape of the SARS-CoV-2 Spike from 1,051 COVID-19 patients d Responsive epitopes are highly variable among patients and correlate with severity d The RBD lacks linear epitopes, but two other regions are rich in linear epitopes d Little neutralization activity is observed for the linear-epitopeelicited antibodies
More than 1000 medical workers have been infected with coronavirus disease 2019 in China. From January 10 th to February 24 th , 2020, a total of 80 medical workers were admitted to Tongji Hospital, Wuhan, including 57 severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) confirmed and 23 clinically diagnosed. The median age was 39 years (interquartile range: 32e48.5), 49 (61.25%) were women, and one patient died. The most common symptoms at onset were fever (65; 81.25%), cough (47; 58.75%), fatigue (28; 35%), myalgia (19; 23.75%), expectoration (19; 23.75%), and diarrhoea (15; 18.75%). Frontline medical workers admitted as patients to this single-centre hospital showed some unique clinical and laboratory findings compared with other patients in Wuhan province and elsewhere.
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