Objectives: We intend to describe early experience using a new, commercially available Micro Plug Set for preterm neonate and infant transcatheter patent ductus arteriosus (PDA) occlusion. Background: Transcatheter PDA occlusion in premature neonates and small infants is safe and effective. The procedure is early in its evolution. Methods: Procedural and short-term outcomes of preterm neonates and infants undergoing transcatheter PDA occlusion with a new, commercially available device were reviewed. Results: Eight preterm neonates and infants born at median 27 weeks gestation (23-36 weeks) underwent transcatheter PDA device closure with the Micro Plug Set. The device is short (2.5 mm) with a range of diameters (3, 4, 5, 6 mm) and delivered through a microcatheter. Procedures were performed at median 41 days of age (12-88 days) and at 1690 g (760-3,310 g). Transvenous PDA device occlusion was performed with fluoroscopic and echocardiography guidance. All procedures were successful with complete PDA occlusion. There were no procedural or short-term adverse events. Conclusions: Preterm neonate and infant transcatheter PDA device closure with a new, commercially available short and microcatheter delivered device (Micro Plug Set) was safe and effective in a small, early series of patients. K E Y W O R D S cardiac catheterization, congenital heart disease, patent ductus arteriosus, premature neonate, preterm infant, vascular occlusion 1 | INTRODUCTION Hemodynamically significant persistent patent ductus arteriosus (PDA) is a common diagnosis among preterm infants that can complicate their postnatal course. Medical, surgical, or transcatheter ductal closure improves outcomes and simplifies clinical management. Transcatheter management is becoming an increasingly accepted practice that has been proven safe and effective. 1-15 Similar to transcatheter management of older PDA patients 16 and other structural heart lesions (atrial septal defect, transcatheter pulmonary valve, transcatheter aortic valve replacement), there is rapid device evolution early in clinical translation. 17-19 Early on, devices traditionally used for transcatheter PDA device closure in older patients were adapted for use in preterm infants, such as, detachable coils, 1-4
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