Chronic Obstructive Pulmonary Disease (COPD) is a growing public health problem in the southern United States, particularly in Alabama. However, very little is known about specific health risk factors disproportionately impacting Alabamians with COPD. We conducted a latent class analysis of 2015–2019 Behavioral Risk Factor Surveillance System data from 4057 Alabamians with COPD (White = 2947, Black = 873, Other = 237). Eighteen risk indicators were examined across three health-related domains: (1) comorbidities, (2) limited healthcare access, and (3) substance use/abuse. Racial disparities between Black and white Alabamians with COPD were assessed using configural similarity analysis. Findings showed that almost one-third (31%) of Alabamians with COPD were in the high-risk class for eight comorbidities, and nearly one-half (48.88%) belonged to the high-risk class for limited healthcare access. Black Alabamians with COPD who did not have health insurance were much more likely to be at high risk for limited healthcare access (94.44%) when compared to their counterparts with insurance (5.56%), χ2(df = 2) = 1389.94, p < 0.0001. Furthermore, the proportion of high-risk, uninsured Black Alabamians with COPD (94.44%) substantially exceeded the percentage of high-risk, uninsured white Alabamians with COPD (59.70%). Most Alabamians with COPD (82.97%) were at low risk for substance use/abuse. Future research should explore new mechanisms for facilitating better healthcare access among high-risk Alabamians living with COPD and other prevalent comorbidities. Greater attention should be focused on Black Alabamians with COPD who cannot afford adequate health insurance.

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This article examines how socioeconomic factors influence physical and mental distress experienced by Alabama adults with chronic obstructive pulmonary disease (COPD) using 2015–2019 data from Behavioral Risk Factor Surveillance System surveys. Alabama adults with COPD who were employed/self-employed, retired, or identified as homemakers were less likely to report physical distress than those unable to work. Younger Alabama adults (25–64 years) with COPD were approximately two times more likely to report mental distress than respondents 65 and older. African Americans with COPD in Alabama were less likely to experience physical distress than Whites. Public health and healthcare practitioners across Alabama can use these state-level findings to direct more targeted, high-yield interventions that will address existing health disparities among Alabama residents with COPD.