The percentage of IOP reduction after cataract surgery in nonglaucomatous eyes with open angles is greater in more anteriorly positioned lenses. Lens position, which is convenient to compute by basic ocular biometric data, is an accessible predictor with considerable predictive value for postoperative IOP change.

Objective To investigate the association between oral contraceptive (OC) use and glaucoma prevalence in the United States. Design Cross-sectional study. Participants 3406 female participants, 40 years of age or older, from the 2005–2008 National Health and Nutrition Examination Survey, who reported a presence or absence of glaucoma or ocular hypertension, completed both the vision and reproductive health questionnaires and underwent eye examinations. Methods Multivariate regression analysis was used to assess the correlation between OC use and self-reported glaucoma or ocular hypertension (n=231 cases), controlling for potential confounders including age, ethnicity, systemic comorbidities such as hypertension and stroke, ocular diseases such as cataract and diabetic retinopathy, reproductive health factors including age at menopause, age at menarche, history of hormone replacement therapy and gynecological surgical history. Main Outcome Measures The outcome variable was self-reported glaucoma or ocular hypertension. Results After adjusting for confounders, those with ≥3 years of OC use had greater odds (odds ratio= 1.94, 95% confidence interval=1.22–3.07) of self-reported glaucoma or ocular hypertension. Other factors associated with higher glaucoma or ocular hypertension prevalence included older age, African American race, and later age of menarche. Conclusion OC use may be associated with increased risk of self-reported glaucoma or ocular hypertension.

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PurposeTo investigate the association between hypothyroidism and glaucomatous disease.MethodsThis cross-sectional study included all subjects above the age of 40 years from two nationwide surveys: the 2008 National Health Interview Survey (NHIS) as well as the 2007 and 2008 National Health and Nutrition Examination Survey (NHANES). The presence or absence of glaucoma, thyroid disease and other demographic and health-related information including comorbidities was ascertained via interview. Blood samples were collected from NHANES subjects and analyzed for thyrotropin (TSH).ResultsA total of 13,599 and 3,839 NHIS and NHANES participants respectively were analyzed to assess for a possible relationship between self-reported glaucoma, and self-reported hypothyroidism as well as self-reported thyroid disease. The unadjusted odds ratio (OR) for NHIS showed a significant association between self-reported glaucoma and self-reported hypothyroidism (OR 1.46, 95% confidence interval [CI] 1.07-1.99). Multivariate logistic regression analysis adjusted for age, gender, race, comorbidities, and health-related behavior, however, showed no association between self-reported glaucoma and hypothyroidism or thyroid disease in both surveys (OR 1.60, 95%CI 0.87-2.95 for NHIS; OR 1.05, 95%CI 0.59-1.88 for NHANES).ConclusionA previously reported association between hypothyroidism and glaucomatous disease was not confirmed in two large U.S. health survey populations. While such an association was noted in the univariate analysis for the NHIS survey, such a relationship was not found in the multivariate analysis after adjustment for potential confounding variables.

Bupropion use, particularly for an extended period of time, may be associated with a reduced risk of glaucomatous disease.

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