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Carboxylic amides Carboxylic amides Q 0490Optimization of α-Acylaminoketone Ecdysone Agonists for Control of Gene Expression. -A series of new α-acylaminoketones [cf. (VIII), 15 examples] are synthesized in an effort to optimize the potency of these compounds as ecdysone agonists. Compound (VIIIa) proves to be the most potent ecdysone agonist of general structure (VIII) to date. -(TICE*, C. M.; HORMANN, R. E.; THOMPSON, C. S.; FRIZ, J. L.; CAVANAUGH, C. K.; SAGGERS, J. A.; Bioorg. Med.