TianQin is a planned space-based gravitational wave (GW) observatory consisting of three Earth-orbiting satellites with an orbital radius of about $10^5 \, {\rm km}$. The satellites will form an equilateral triangle constellation the plane of which is nearly perpendicular to the ecliptic plane. TianQin aims to detect GWs between $10^{-4} \, {\rm Hz}$ and $1 \, {\rm Hz}$ that can be generated by a wide variety of important astrophysical and cosmological sources, including the inspiral of Galactic ultra-compact binaries, the inspiral of stellar-mass black hole binaries, extreme mass ratio inspirals, the merger of massive black hole binaries, and possibly the energetic processes in the very early universe and exotic sources such as cosmic strings. In order to start science operations around 2035, a roadmap called the 0123 plan is being used to bring the key technologies of TianQin to maturity, supported by the construction of a series of research facilities on the ground. Two major projects of the 0123 plan are being carried out. In this process, the team has created a new-generation $17 \, {\rm cm}$ single-body hollow corner-cube retro-reflector which was launched with the QueQiao satellite on 21 May 2018; a new laser-ranging station equipped with a $1.2 \, {\rm m}$ telescope has been constructed and the station has successfully ranged to all five retro-reflectors on the Moon; and the TianQin-1 experimental satellite was launched on 20 December 2019—the first-round result shows that the satellite has exceeded all of its mission requirements.

There has been increasing concern that the overuse of antibiotics in livestock farming is contributing to the burden of antimicrobial resistance in people. Farmed animals inEurope and North America, particularly pigs, provide a reservoir for livestock-associated methicillin-resistant Staphylococcus aureus (LA-MRSA ST398 lineage) found in people. This study is designed to investigate the contribution of MRSA from Chinese pig farms to human infection. A collection of 483 MRSA are isolated from 55 farms and 4 hospitals in central China, a high pig farming density area. CC9 MRSA accounts for 97.2% of all farm isolates, but is not present in hospital isolates. ST398 isolates are found on farms and hospitals, but none of them formed part of the "LA-MRSA ST398 lineage" present in Europe and North America. The hospital ST398 MRSA isolate form a clade that is clearly separate from the farm ST398 isolates. Despite the presence of high levels of MRSA found on Chinese pig farms, the authors find no evidence of them spilling over to the human population. Nevertheless, the ST398 MRSA obtained from hospitals appear to be part of a widely distributed lineage in China. The new animal-adapted ST398 lineage that has emerged in China is of concern.

Chronic inflammation plays a pivotal role in cancer development. Cancer cells interact with adjacent cellular components (pro-inflammatory cells, intrinsic immune cells, stromal cells, etc.) and non-cellular components to form the inflammatory tumor microenvironment (TME). Interleukin 6 (IL-6), macrophage migration inhibitory factor (MIF), immune checkpoint factors and other pro-inflammatory cytokines produced by intrinsic immune cells in TME are the main mediators of intercellular communication in TME, which link chronic inflammation to cancer by stimulating different oncogenic signaling pathways and improving immune escape to promote cancer development. In parallel, the ability of monocytes, T regulatory cells (Tregs) and B regulatory cells (Bregs) to perform homeostatic tolerogenic functions is hijacked by cancer cells, leading to local or systemic immunosuppression. Standard treatments for advanced malignancies such as chemotherapy and radiotherapy have improved in the last decades. However, clinical outcomes of certain malignant cancers are not satisfactory due to drug resistance and side effects. The clinical application of immune checkpoint therapy (ICT) has brought hope to cancer treatment, although therapeutic efficacy are still limited due to the immunosuppressive microenvironment. Emerging evidences reveal that ideal therapies including clearance of tumor cells, disruption of tumor-induced immunosuppression by targeting suppressive TME as well as reactivation of anti-tumor T cells by ICT. Here, we review the impacts of the major pro-inflammatory cells, mediators and their downstream signaling molecules in TME on cancer development. We also discuss the application of targeting important components in the TME in the clinical management of cancer.

Triple-negative breast cancer (TNBC) is a highly lethal malignancy with limited therapy options. TWIST1, a key transcriptional factor of epithelial-mesenchymal transition (EMT), contributes to self-renewal of cancer stem-like cells (CSCs), chemo-resistance, metastasis, and TNBC-related death. However, the mechanism by which TWIST1 is deregulated in TNBC remains elusive. Here, USP29 is identified as a bona fide deubiquitinase of TWIST1. The deubiquitination of TWIST1 catalyzed by USP29 is required for its stabilization and subsequent EMT and CSC functions in TNBC, thereby conferring chemotherapeutic resistance and metastasis. Furthermore, the results unexpectedly reveal that CDK1 functions as the direct USP29 activator. Mechanistically, CDK1-mediated phosphorylation of USP29 is essential for its deubiquitinase activity toward TWIST1 and TWIST1 driven-malignant phenotypes in TNBC, which could be markedly mitigated by the genetic ablation or pharmacological inhibition of CDK1. Moreover, the histological analyses show that CDK1 and USP29 are highly upregulated in TNBC samples, which positively correlate with the expression of TWIST1. Taken together, the findings reveal a previously unrecognized tumor-promoting function and clinical significance of the CDK1-USP29 axis through stabilizing TWIST1 and provide the preclinical evidence that targeting this axis is an appealing therapeutic strategy to conquer chemo-resistance and metastasis in TNBC.

The TianQin Project is aiming at gravitational wave (GW) detection in space. TianQin GW observatory comprises three satellites orbiting on $1 \times 10^5$ km Earth orbits to form an equilateral-triangle constellation. In order to minimize the variations of arm-length and breathing angle, the satellites must be launched and adjusted precisely into an optimized orbit. Therefore, satellite laser ranging must be used to enhance the precision of satellite’s orbit determination. To develop the capability of satellite laser ranging for TianQin’s orbit, the TianQin Laser Ranging Station has been designed and constructed to perform high-precision laser ranging for TianQin satellites and lunar laser ranging as well. Applying a 1064-nm Nd:YAG laser with 100-Hz repetition frequency, 80 pico-second pulse duration, and $2 \times 2$ array of superconducting nanowire single photon detectors, we have obtained the laser echo signals from the five lunar retro-reflector arrays, and the measurement data have been packaged into 234 normal points, including a few data measured during the full-moon lunar phase. Each NP is calculated from continuous measurement for about ten minutes and the statistical error of the normal points is about 7 mm (1$\sigma$).

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High-repetition-rate lunar laser ranging (LLR) has great prospects and significance. We have successfully obtained the effective echo signals of all five corner-cube reflectors (CCRs) on the lunar surface by using a 100 Hz repetition rate. This method can effectively improve the detection ability but has some defects: for example, the main wave and echo signals overlap. In this paper, the frequency selection and signal overlap are theoretically analyzed. The results show that the existing target prediction accuracy can meet the requirement of a 100 Hz repetition rate LLR. In the experiment, the use of a high-repetition-rate pulse laser allowed us to obtain detailed CCR information, such as the column number of CCRs, which will prove that the effective echo signals of LLR are reflected by the CCRs. Finally, we propose to use the resolved data to calculate the precision of inner coincidence and believe the accuracy can be within a millimeter.

As the signal reflected by the corner-cube reflector arrays is very weak and easily submerged during the full moon, we analyze the influence of the thermal effect of corner-cube reflector arrays on the intensity of lunar laser ranging echo. Laser ranging measurements during the penumbra lunar eclipse verify suspected thermal deformation in the Lunakhod 2 reflectors. Signal levels vary over two orders of magnitude as the penumbra eclipse progresses. This can be explained by the change in the dihedral angle of the corner-cube reflectors caused by the temperature. The results show that when the dihedral angle errors reach 1″, the energy is reduced by 100 times compared with the ideal corner-cube reflector. In the experiment, our findings suggest that when the corner-cube reflector arrays enter the penumbra of the earth, the effective echo signal level which reaches 0.18 photons/s far exceeds the historical level of the full moon. However, 11 minutes after the penumbra lunar eclipse, the effective echo rate of Lunakhod 2 will drop two orders of magnitude. The mechanism can explain the acute signal deficit observed at full moon.