Background:
Few studies have described lymphocytic interstitial pneumonia (LIP) in
Sjögren's syndrome (SS). We aimed to analyze the clinical, therapeutic, and outcome of patients
with SS and LIP.
Methods:
We searched for articles in PubMed/MEDLINE, LILACS, SciELO, and Cochrane from
1966 to 2020, in English, Spanish, French, Chinese, and Japanese literature had an English summary about LIP and SS. The keywords were "Sjögren syndrome" and "Lymphocytic interstitial
pneumonia." Additionally, we report a patient with SS and LIP.
Result:
27 patients with SS and LIP were found. The age range ranged from 14 to 73 years old, with
only 3 male patients, with a predominance of LIP cases in patients with primary SS (22/27). In the
following case, the LIP preceded SS by 2 years; in the other 26 patients, SS preceded it. The majority presented dyspnea, mainly on exertion, followed by a dry cough. Lung biopsy was performed in
10 studies. Therapy varied from the use of clinical observation, corticosteroids alone, or associated
with immunosuppressants. Most studies have shown improvement or stabilization of the pulmonary
condition after therapy (13/16 studies).
Conclusion:
This article reviews cases of lymphocytic interstitial pneumonia associated with
Sjögren syndrome and shows a good outcome with adequate treatment. It emphasizes that early LIP
diagnosis in patients with Sjogren Syndrome may be determined using lung computed tomography.
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