The green potential of the sharing economy to exploit underutilised or redundant resources has generated a considerable interest and expectations on the part of government institutions, investors and consumers. Alongside the emerging green logic, more established economic and social logics appear to be critical for growth of sharing platforms. Applying an institutional logics approach, this paper investigates how entrepreneurial teams in the sharing economy deal with this complexity of expectations of various constituents and institutions. Based on 30 semi-structured interviews with founders and executives of UK sharing platforms, we examine the strategies used by entrepreneurial teams to utilise and combine the green logic with other institutional logics present. The results demonstrate that sharing platforms are able to grow via utilising the green logic together with the economic and social logics in a flexible manner, applying complexity reducing and complexity absorbing strategies as well as temporal adjustments in the use of logics.
Objective: Acute Lymphoblastic Leukemia (ALL) consists of excessive proliferation of lymphoblasts. The frequency of Human Leukocyte Antigen (HLA)-DR53 (DRB4) homozygosity and allele was found to be higher in male childhood ALL cases. The aim of this study was to identify the HLA-DR53 allele frequency; interferon-inducing double chain ribonucleic acid binding protein kinase A pseudogene 1 (PRKRAP1) positivity; rs2395185 allele and genotype frequencies in ALL patients.
Materials and Methods:Sixty ALL patients and 40 healthy controls were studied. HLA's were analyzed using the PCR-SSP. The PRKRAP1 positivity have been identified by PCR and rs2395185 genotypes were determined by TaqMan assay using real-time PCR.Results: PRKRAP1 positivity was shown to be specific to HLA-DRB4 haplotype in the whole group. We observed that HLA-DRB1*04, DRB1*07 alleles were higher in male patients (43.5%, 25.0%) compared with female patients (25.0%, 21.4%). The prevalence of rs2395185 T allele, HLA-DRB4 allele and HLA-DRB4 homozygous in childhood ALL patients were significantly higher in males compared with the females (p:0.044, p:0.007, p:0.045, respectively).
Conclusion:The molecular mechanism of PRKRAP1 pseudogenesis, which we have confirmed to be specific for HLA-DRB4 (DR53) haplotypes, in a newly identified specific transcription map can be investigated and its relationship with ALL can be determined.
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