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OBJECTIVE -Endothelial markers endothelin 1 (ET-1) and von Willebrand factor (vWF) were assessed in patients with type 2 diabetes and dyslipidemia and in patients with hypercholesterolemia.RESEARCH DESIGN AND METHODS -In this case-control study, plasma ET-1 and vWF levels were measured by enzyme-linked immunosorbent assay in 35 normoalbuminuric type 2 diabetic patients with dyslipidemia (56 ± 5 years), in 21 nondiabetic patients with hypercholesterolemia (52 ± 7 years), and in 19 healthy control subjects (45 ± 4 years).All of the individuals were normotensive and nonsmokers. Urinary albumin was measured by immunoturbidimetry.RESULTS -ET-1 levels were higher (P Ͻ 0.0001) in type 2 diabetic dyslipidemic patients (1.62 ± 0.73 pg/ml) than in both nondiabetic hypercholesterolemic patients (0.91 ± 0.73 pg/ml) and control subjects (0.69 ± 0.25 pg/ml). vWF levels were significantly increased (P = 0.02) in type 2 diabetic (185.49 ± 72.1%) and hypercholesterolemic (163.29 ± 50.7%) patients compared with control subjects (129.70 ± 35.2%). In the multiple linear regression analysis, ET-1 was significantly associated (adjusted r 2 = 0.42) with serum triglyceride levels (P Ͻ 0.001), age (P Ͻ 0.01), insulin sensitivity index (P Ͻ 0.02), and albuminuria levels (P Ͻ 0.04). vWF levels were associated (adjusted r 2 = 0.22) with albuminuria (P Ͻ 0.001), fibrinogen levels (P Ͻ 0.02), and BMI (P Ͻ 0.03).CONCLUSIONS -Compared with hypercholesterolemic patients, type 2 diabetic patients with dyslipidemia have increased levels of ET-1 and vWF, which may indicate more pronounced endothelial injury. These findings appear to be related to components of the insulin resistance syndrome.

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Early and progressive increase in sTNFR1 and sTNFR2 levels is associated with higher risk for poor outcome in severely burned patients.