Background There is increasing evidence that long noncoding RNAs are involved in hepatocellular carcinoma (HCC) tumorigenesis. The expression level of TRPM2-AS in HCC and its clinical association remain poorly defined. Method qRT-PCR was performed to detect the expression of TRPM2-AS in 108 HCC patients. The correlations between TRPM2-AS expression and clinicopathological factors and prognosis were evaluated. The inference of TRPM2-AS to the proliferation and apoptosis of HCC cells was detected. Aims The aim of our study was to explore the expression of TRPM2-AS in hepatocellular carcinoma (HCC) and the relation with prognosis and clinical features. Results The expression of TRPM2-AS was higher in most HCC tissues and was significantly correlated with tumor size, AJCC stage, tumor differentiation, and the prognosis of HCC patients. Interfering TRPM2-AS expression using siRNA significantly inhibited cell proliferation and promoted cell apoptosis in two HCC cell lines. Conclusion Long non-coding RNA TRPM2-AS is upregulated in HCC and represents a new biomarker for HCC and the inhibition of TRPM2-AS promotes apoptosis in HCC cells in vitro.

Objective Traditionally, oestrogens were considered to be protective for the cardiovascular system for premenopausal women. Therefore, we conducted a retrospective case-control study to examine the association between endogenous oestrogens and acute myocardial infarction (AMI) risk among postmenopausal women. Methods A case-control study was performed among 30 primary AMI patients and 60 control subjects. Baseline characteristics data was collected and endogenous sex hormones levels were determined using chemoluminescence and radioimmunoassay methods. Conditional logistic regression models were developed with adjustment for confounders. Results Compared with controls, the circulating oestrone, oestradiol, androstenedione and testosterone levels were significantly higher in AMI patients (P < 0.05) while the sex hormone binding globulin (SHBG) level was lower (P<0.05). Spearman correlation coefficients showed oestradiol was positively correlated with body mass index (BMI) and waist-to-hip ratio (WHR) in cases, but not in controls. In univariable conditional logistic regression models, oestrone, oestradiol, testosterone, WHR, BMI, diabetes and hypertension were all found to be positively associated with AMI (P<0.05). After adjusting for these factors, oestradiol (odds ratio (OR)04.75; 95 % confidence interval (CI)01.07-21.10; P00.04) and WHR (OR06.46; 95 % CI01.09-38.39; P00.04) continued to demonstrate strong positive associations with AMI. Conclusions A higher level of oestradiol was potentially associated with primary AMI risk among postmenopausal women.

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Room-temperature multiferroic Bi 4 YFeTi 3 O 15 thin films of four-layered perovskite, Abstract Polycrystalline Bi 4 YFeTi 3 O 15 thin films were prepared on (111)Pt/Ti/SiO 2 /Si through a sol-gel process. X-ray diffraction analysis shows the films have a single-phase four-layered Aurivillius structure with the space group of Fmm2. As expected, the Bi 4 YFeTi 3 O 15 films exhibit the coexistence of ferroelectric and weak ferromagnetic properties with the remanent polarization (2P r ) ~ 53.62 µC/cm 2 and the saturated magnetization (M s ) ~ 0.50 emu/cm 3 at room temperature. More interestingly, both dielectric relaxation behavior and room-temperature magneto-dielectric effect were observed in the Bi 4 YFeTi 3 O 15 films, probably resulting from the coexistence of Fe 2+ and Fe 3+ . The conduction mechanism of the films from 10 to 300 kV/cm is dominated by Ohmic mechanism, space-charge-limited current (SCLC), and M A N U S C R I P T A C C E P T E D ACCEPTED MANUSCRIPTtrap-filled-limit (TFL) current, respectively. The leakage current density remains lower than 1.03×10 -5 A/cm 2 under the poling field below 300 kV/cm at 300 K.

In summary, the results of this study suggest that optical spectroscopy can monitor the hemodynamic profile in diabetic subjects with chronic periodontitis. Furthermore, healthy sites of diabetic subjects presented lower tissue oxygenation than did those of nondiabetic subjects.