The development of a large-cell non-Hodgkin's lymphoma in a patient suffering from chronic lymphocytic leukaemia is known as Richter's syndrome, representing one of the possible anaplastic transformations of the leukaemia. Cutaneous involvement is an extremely rare event. The case of a 45-year-old man with B-cell chronic lymphocytic leukaemia is reported. Five years later multiple cutaneous nodules developed on his extremities. Biopsies of the skin showed a diffuse large-cell lymphoma, bearing the same cell surface immunoglobulin light chain isotype as the leukaemia, suggesting the original relationship between both neoplasms.

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A 70-year-old patient who presented with a mass on the dorsum of his nose of 2 years evolution is reported. Histologically it was formed by dermal nests and cords of atypical epithelial cells surrounded by an intense inflammatory infiltrate composed of lymphocytes and histiocytes of an usual aspect. The lesion was removed, relapsing 2 years later. The ultrastructural and immunohistochemical results are discussed. We compare another six cases of lymphoepithelioma-like carcinoma, reported in the literature. The differential diagnosis with other related conditions is discussed together with its possible adnexal origin.

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