What are the novel findings of this work? This is the first prospective multicenter study evaluating the International Endometrium Tumor Analysis (IETA) terms and definitions in women with abnormal uterine bleeding, before and after menopause. Both unenhanced sonography and fluid-instillation sonography were evaluated and compared with histology. What are the clinical implications of this work? Our study provides didactic, evidence-based data on the sonographic findings of the normal and abnormal endometrium. This will help clinicians in the diagnosis of malignant as well as benign endometrial pathology. We also describe some easy-to-assess features which, when detected, make endometrial cancer very unlikely.

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Infection with parvovirus H-1 strongly interfered with the proliferation of non-established tissue cultures derived from human breast tumors, but had little effect on the growth of corresponding normal human mammary cells. Even though tumor cells were always more sensitive to the virus than normal tissue from the same patient, appreciable quantitative differences were observed among tumor specimens. With time and sub-cultures, the killing effect of the virus on tumor cells became amplified. The impaired growth of infected tumor cells was due both to cytotoxic and to cytostatic action of H-1 virus and was associated with their greater capacity for virus-DNA amplification as compared with normal cells.

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Objectives To compare three-dimensional (3D) (OR, 0.6 (95% CI,, P < 0.05) and VFI (OR, 0.4 (95% CI,, P < 0.05). Conclusion Vascular density, ischemic necrosis and histological cellular activity score are statistically significantly