We report the case of a 51-old truck driver who died by acute myocardial infarction as a result of a large size cardiac fibroma of the left ventricle. We also include some remarks about the etiology and the most favorable therapeutic strategy for the disease. The cardiac tumors are very rare and vary with age, which can be a clue for their correct diagnosis. The rhabdomyomas and fibromas are commonly seen in childhood while papillary fibroelastoma, mixoma and lipoma are more often found in adults. Cardiac fibroma is an extreme rare cardiac tumor. Its diagnosis is a challenging issue without immunohistochemistry. We used vimentin, desmin, muscle actin, CD34, S100 to proof the origin of this tumor. The second issue we rise is the superficial medical examination done periodically by professional drivers. According with the Bihor County Forensic Department records this is the only case of cardiac fibroma in the last 15 years.
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