None of these risk factors were contraindications to laparoscopic cholecystectomy. This may help predict the difficulty of the procedure and permit the surgeon to better inform patients about the risk of conversion from laparoscopic to open cholecystectomy.
In the present study, we have aimed to characterize the intrinsic, extrinsic and ER-mediated apoptotic induction by hyperthermia in an in vitro model of human malignant melanoma and furthermore, to evaluate its therapeutic effectiveness in an adjuvant therapeutic setting characterized by combinational treatments with non-targeted (Dacarbazine & Temozolomide) and targeted (Dabrafenib & Vemurafenib) drugs. Overall, our data showed that both low (43 °C) and high (45 °C) hyperthermic exposures were capable of inducing cell death by activating all apoptotic pathways but in a rather distinct manner. More specifically, low hyperthermia induced extrinsic and intrinsic apoptotic pathways both of which activated caspase 6 only as opposed to high hyperthermia which was mediated by the combined effects of caspases 3, 7 and 6. Furthermore, significant involvement of the ER was evident (under both hyperthermic conditions) suggesting its role in regulating apoptosis via activation of CHOP. Our data revealed that while low hyperthermia activated IRE-1 and ATF6 only, high hyperthermia induced activation of PERK as well suggesting that ultimately these ER stress sensors can lead to the induction of CHOP via different pathways of transmitted signals. Finally, combinational treatment protocols revealed an effect of hyperthermia in potentiating the therapeutic effectiveness of non-targeted as well as targeted drugs utilized in the clinical setting. Overall, our findings support evidence into hyperthermia’s therapeutic potential in treating human malignant melanoma by elucidating the underlying mechanisms of its complex apoptotic induction.
Results from a partial-wave analysis of the decay J/y/-+ yK §K ± n "*" in the K §K ± n + invariant-mass range 1.35-1.6 GeV/c 2 are presented. Within the isobar model, the data in this mass range are best described by a mixture of 0~+ and 1 ++ amplitudes, corresponding to the A r *A' + c.c. (P wave), A^A' + c.c. (5 wave), and <2o(980)/r (5 wave) channels. These results show that r/(1430) is not a J PCs =0 ~ + flo(980);r resonance, but a mixture of overlapping states.
We have measured the differential production cross sections as a function of scaled momentum x p ϭ2 p/E c.m. of the identified hadron species ϩ , K ϩ , K 0 , K* 0 , , p, ⌳ 0 , and of the corresponding antihadron species in inclusive hadronic Z 0 decays, as well as separately for Z 0 decays into light (u, d, s), c and b flavors. Clear flavor dependences are observed, consistent with expectations based upon previously measured production and decay properties of heavy hadrons. These results were used to test the QCD predictions of Gribov and Lipatov, the predictions of QCD in the modified leading logarithm approximation with the ansatz of local parton-hadron duality, and the predictions of three fragmentation models. The ratios of production of different hadron species were also measured as a function of x p and were used to study the suppression of strange meson, strange and non-strange baryon, and vector meson production in the jet fragmentation process. The light-flavor results provide improved tests of the above predictions, as they remove the contribution of heavy hadron production and decay from that of the rest of the fragmentation process. In addition we have compared hadron and antihadron production as a function of x p in light quark ͑as opposed to antiquark͒ jets. Differences are observed at high x p , providing direct evidence that higher-momentum hadrons are more likely to contain a primary quark or antiquark. The differences for pseudoscalar and vector kaons provide new measurements of strangeness suppression for high-x p fragmentation products. ͓S0556-2821͑99͒06101-9͔
A new technique is applied to data collected at the 0(3770) resonance to derive charmed-Dmeson branching fractions without relying on the measurement of D-production cross sections. Measurements are presented for three decay modes of the D° (K~TT + , D~ * and K-TT + TT 0 ) and four decay modes of the D + (K~7r + 7r + , K-TT + TT + TT 0 , K$<7T + , and tf 5°i r + ir 0 ). The resulting branching fractions are significantly larger than previous measurements.
We present measurements of the two-body decays of the J/$ into a vector and a pseudoscalar meson. The data, taken with the Mark I11 detector at the SLAC e + e -storage ring SPEAR, consist of 5.8 X lo6 produced J/+'s. The branching ratios for the J/$ decays into pn, pg, pq', on0, og, wg', $17, r#Jgl, and K*K are measured; an upper limit on J / $ -~T ' is obtained. Using the measured branching ratios we obtain parameters of a phenomenological model of J/$ decays, indicating that the g and g' are consistent with being composed only of light and strange quarks. The model is used to obtain the mixing angle in the pseudoscalar nonet. The m a 0 electromagnetic form factor is determined. The upper limit on J/*-+r#Jno is used to study the contributions from electromagnetic doubly-Okubo-Zweig-Iizuka-suppressed decays of the J/+.
Previous abdominal operations, even in the upper abdomen, are not a contraindication to safe laparoscopic cholecystectomy. However, previous upper abdominal surgery is associated with an increased need for adhesiolysis, a higher open conversion rate, a prolonged operating time, an increased incidence of postoperative wound infection, and a longer postoperative stay.
Mucocele of the appendix is an uncommon disorder, characterized by a cystic dilatation of the lumen. It is often diagnosed clinically from signs and symptoms of acute appendicitis or, if it is asymptomatic, as an incidental finding during ultrasonography, computed tomography, and radiographic examinations of the gastrointestinal tract, or laparotomy. The incidence of mucocele ranges from 0.2% to 0.3% of all appendectomy specimens. We report five cases of appendiceal mucocele (all women, aged 19-90 years), who were admitted from January 1993 to January 2003 to our hospital. These cases represent 0.29% of the 1720 appendectomies performed during this period. Three of the patients were symptomatic and had appendectomies. The final diagnosis for mucocele was given at laparotomy. No colon neoplasms were identified during surgery, and subsequent colonoscopic examinations were also negative. The other two patients were asymptomatic of appendiceal tumor. Colonoscopy revealed two colonic malignant tumors in one patient and an adenocarcinoma of the sigmoid colon in the other. Mucocele of the appendix was diagnosed pre-operatively by ultrasound and computed tomography. One of the two patients underwent a right hemicolectomy and sigmoidectomy; the other one underwent an appendectomy, cecostomy and sigmoidectomy. Four of the patients recovered and are doing well today; one patient died on the twenty-fifth postoperative day. The most common symptom of mucocele is abdominal pain, although many patients may be asymptomatic. Mucocele is often associated with concomitant colon cancer, thus patients with this tumor should be systematically checked for other colonic lesions.
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