The study comprised of 60 Candida spp., 50 isolates from HIV and TB positive individuals (immunocompromised) and 10 isolates from non-HIV and -TB patients (immunocompetent). Among the 60 Candidal isolates, 83.3% were identified as C. albicans, 11.6% as C. glabrata and rest 5% as C. krusei. There is no study in production pattern of extracellular enzymes of Candida spp. isolated from HIV and TB patients in comparison with non-HIV and -TB patients in India. The comparison of phospholipase activities showed that there was a significant difference between the groups at (P = 0.001). The non-HIV and -TB groups of C. glabrata and C. krusei did not show detectable phospholipase activity when compared to the HIV and TB groups. The mean difference in the phospholipase activities of these two groups was significant (P = <0.001). Candida spp. of both the groups do not possess the ability to hydrolyze gelatin. All the strains possessed the ability to show alpha haemolysis. Even though it had shown alpha haemolysis, the significant difference in haemolytic activity was observed only in C. albicans (P = <0.001). None of the isolates from the two groups possessed the ability to hydrolyze gelatin. In the resistance profile of Candida spp., C. albicans of HIV and TB groups had shown resistance to fluconazole, Itraconazole, ketaconazole, nystatin but showed 100% sensitivity towards amphotericin-B. The isolates of C. krusei and C. glabrata showed no resistance to any of the drugs tested. In the case of, non-HIV and -TB patients the resistance pattern was low.
Curcumin is an active compound extracted from the rhizomes of Curcuma longa L. (Turmeric). It possesses a di phenolic structure and there are three important fractions of curcumin namely curcumin, mono-desmethoxycurcumin and bis-desmethoxycurcumin. Curcumin is having high medicinal value. It is widely in Ayurveda, Siddha and Unani medicine formulations to treat various diseases. It is effective against microbial pathogens like bacteria, virus and fungi. It is highly potent and kills cancerous cells. Curcumin exhibits antioxidant activity and reduces lipoperoxidation. Cardioprotective nature of curcumin is also reported. It can protect the brain from neurodegenerative disorders caused by oxidative stress. It is safe to use in humans and animals. In addition to its medicinal value, it is also having numerous commercial applications like dyeing, cooking purposes and antiseptics etc. The cultivation of turmeric by means of inorganic inputs makes it contaminated with heavy metals is reported. Improving the biological use of curcumin provides healthy humankind and increases the economic status of a country.
In the present study, the effort has been taken to analyze the effects caused by agrochemicals. The best alternative to agrochemicals is biofertilizers. It is necessary to understand the beneficial role played by biofertilizer in crop production and regaining the soil fertility. Thus, the present study compares the effect of agrochemicals [fertilizers (urea), fungicide (carbendazim) and insecticide (endosulfan)] and biofertilizers (Azotobacter sp.) on maize under nursery trials were carried out in Complete Randomized Block Design (CRBD) by altering the present recommendation. The effect of above-mentioned treatments was studied based on the maize growth, phytochemical concentrations, soil fertility level and microbial population. The treatment with Azotobacter sp. and actual recommended dose of urea were performing well when compared to other agrochemical treatments. The higher the concentration of agrochemical application, lower is the plant growth. It is incurred from the study that generally the usage of agrochemicals was seriously disturbing plant biotic characters and soil ecology.
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