Introduction In order to determine the prevalence of anaemia and to explore the associations between iron status and intake in the process of pregnancy, we compared the dietary and total intake of iron with the Dietary Reference Intakes (DRIs) for Japanese in a population of pregnant women in the suburbs. Methods A total of 109 pregnant women participated in the survey and were measured for blood haemoglobin (Hb). For 42 (mean age 6SD: 30.264.5) clinically normal pregnant women (Hb concentration >11 g/dl) in the first trimester of pregnancy, we used the dietary record methods for two consecutive weekdays and a weekend day with a handy camera, to examine dietary intake of iron in the second trimester. Dietary intake analysis was performed using Healthy Maker Pro 501 software, Mushroom-soft. Statistical analysis was performed with SPSS for Windows, Version 11.5. Blood haemoglobin, haematocrit, serum iron, and ferritin were measured at the third trimester. Results At the first trimester, anaemia was diagnosed in 48.6% of the subjects (Hb <11.0 g/dl). At the second trimester, iron intake was lower than the estimated average requirement of DRIs (16.5 mg/day) in 93% of the subjects. The level of latent iron deficiency anaemia (Ferritin <12 ng/dl) was 88.1% and the anaemia (Hb <11.0 g/dl) was 52.4% at the third trimester. Conclusion The results of our study support that the iron deficiency anaemia is a physiological adaptation for prevention of thrombosis during pregnancy. Introduction Stage of disease at presentation of cancer is not routinely recorded in medical records, resulting in large amounts of missing data. We investigated survival trends by ethnicity among 0e29 year olds with cancer while using multiple imputation (MI) to impute missing values of stage. Method Subjects (n¼3534) diagnosed with cancer in Yorkshire (1990e2005) were analysed. Individual imputation models were used to assign stage of disease to four main diagnostic groups; leukaemia, lymphoma, central nervous system (CNS) and other solid tumours. Linear regression was used to impute white blood cell count (WCC) for leukaemia as a proxy for stage and ordinal logistic regression was used to impute for the remaining diagnostic groups. The survival analysis was performed using Cox regression. SP1-75Results Missing stage data occurred in 66% of cases for lymphoma, 28% for CNS tumours, and 69% for other solid tumours. WCC was missing for 57% of leukaemia cases. Results of the final analysis showed an increased risk of death for south Asians compared to non-south Asians with leukaemia (HR 1.61; 95% CI 1.01 to 2.55) and lymphoma (HR 2.05; 95% CI 1.09 to 3.87), and a decreased risk for south Asians with other solid tumours (HR 0.50; 95% CI 0.28 to 0.89). There was no significant difference by ethnic group for those with CNS tumours (HR 1.51; 95% CI 0.82 to 2.78). Conclusion Although stage was missing in two-thirds of cases overall, MI was used to minimise bias and enhance the precision of analyses. This technique therefore offers considerable advantages ov...
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